In vitro fertilization, also known as in vitro fertilization, is the process of combining eggs and sperm in a laboratory environment and transferring the resulting embryo to the mother's uterus.
It was first introduced in 1978 by British scientist Prof. Dr. Robert Edwards.
Dr. Edwards was awarded the Nobel Prize in Medicine in 2010 for finding the "in vitro fertilization" (IVF) treatment method.
We know that no two patients are alike, so our priority is to evaluate you properly for the most appropriate treatment. With our experience, we are able to identify unique trends that lead to success in the rarest cases of infertility.
If you have been unprotected for 1 year and no pregnancy has occurred, infertility investigations should be initiated.
In such cases, our couples should be referred to IVF.
In men, the medical necessity for the storage of reproductive cells and gonadal tissues are as follows
In women, medical necessity requires the storage of reproductive cells and gonadal tissues;
In Turkey, single women with low egg reserve, a condition that can damage the reproductive organs and who will undergo surgery or treatment can undergo egg freezing.
The abdominal egg retrieval procedure is performed under anesthesia by inserting a needle through a point in the abdomen, accessing the egg tissue and collecting the developed eggs. This procedure has the same risks as vaginal egg retrieval, but in experienced hands this risk can be reduced.
It is the process of selecting live sperm with the help of a pipette, piercing the egg and releasing the sperm into the egg.
The aim of the IVF process is to ensure the development of a large number of eggs.
Treatment is started with an ultrasound on the 2nd or 3rd day of menstruation. The dose of medication to start treatment may vary according to the patient's egg reserve and weight.
Although the duration of use of the drugs started for egg enlargement varies according to the patient's response, it is usually between 8-12 days. Drug doses and treatment protocols are determined specifically for each patient and individualized treatment protocols are applied.
At the end of this period, egg collection is performed under anesthesia. After egg collection, the embryo development process begins and embryo transfer is performed on the 2nd, 3rd or 5th day.
Our patients whose transfer process is completed are advised to reduce their physical activity in the following process, and especially our patients coming from out of town or abroad are informed that they can travel the next day.
Phase 1: Treatment is started with an ultrasound performed on the 2nd or 3rd day of menstruation. Although the duration of use of the drugs started to enlarge the egg varies according to the patient's response, it is usually between 8-12 days. At the end of this period, egg collection is performed under anesthesia. Following the egg retrieval, the embryo development monitoring process begins and the embryos are frozen on the 2nd, 3rd or 5th day.
In patients in whom genetic testing is planned, embryo freezing is performed on the 5th or 6th day. While the biopsied embryo is frozen, the biopsy material is sent for genetic testing.
Stage 2: Our patients who have completed egg retrieval are expected to start menstruating within a week or 10 days.
The embryo transfer stage can be started in the menstrual period immediately following the egg collection or in the following menstrual periods.
On the 2nd or 3rd day of the menstrual period, the uterine wall thickness can be monitored by following the estrogen hormone administered orally, through the skin or vaginally, or the naturally developing egg in order to increase the uterine wall thickness. This period is usually between 10 and 15 days, but when the appropriate thickness and hormone levels are achieved, the embryo transfer day is determined.
Patients who have started estrogen hormone on the 2nd or 3rd day of menstruation are called for a follow-up visit for ultrasound and blood tests 12 or 15 days after the start of the hormone.
Embryo transfers are completed within 1 week from that day for couples with appropriate uterine wall thickness and hormone levels. Our patients whose transfer process is completed are advised to reduce their physical activity in the following process, and especially our patients coming from out of town or abroad are informed that they can travel the next day.
Today, the most common question we receive from our couples after embryo transfer is how many days should I rest? In our general practice, our recommendation to our couples is that they should be at rest for a few days. However, when we examine the scientific data, this does not have to be the case.
In an analysis of 21598 patients in 2022, moving or bed rest immediately after embryo transfer does not affect pregnancy outcomes. Therefore, given the scientific studies, absolute bed rest after embryo transfer is not necessary.
Our patients who have undergone egg retrieval, embryo development and embryo biopsy should wait between 2 and 4 weeks for the genetic test results to be reported.
For this reason, our couples whose embryo procedures have been completed must wait for the genetic test results. Often, our couples who have received the report results after skipping a menstrual period can start the embryo transfer process on the 2nd or 3rd day of the next menstrual period after skipping 1 menstrual period.
What is the upper limit for the number of IVF trials? There is also no clear study on this.
In the study conducted by American scientists, looking at the current data, approximately 90% of couples who have transferred embryos that have passed genetic testing 3 times take a baby home.
Although it is not clear how many times IVF can be attempted in total, the woman's age, egg reserve, and the presence or absence of additional diseases are more important for the number of attempts.
Although the long-term effects of the drugs used during treatment on human health are not clear, the maximum number of attempts is planned according to the psychosocial status of the couples.
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06.06.2023Dear couples and readers, you can review our topics below for all your questions about IVF treatment and infertility and answers to any questions you may have. All you wonder about IVF, infertility and gynecological diseases...
When success is expressed as pregnancy rate, it is generally known to be inversely proportional to increasing age. As the woman's age increases, the success rate of IVF decreases.
The AMH hormone, which indicates low egg reserve, is secreted from preantral egg cells, called precursor egg cells, in the ovarian tissue of women.
The use of PRP in the field of reproductive medicine has increased and become popular. Low ovarian reserve, menopause and endometrium (inner sheath of the uterus) have become new areas where PRP is used.
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