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Low Egg Reserve (Amh)

Low Egg Reserve (Amh)

Low Egg Reserve (Amh) and IVF Success

In IVF treatment, the two most important factors affecting the success rate of IVF are the woman's age and low egg reserve, i.e. low AMH level.

What is the low egg reserve (AMH) test?

The AMH hormone, which indicates low egg reserve, is secreted from preantral egg cells, called precursor egg cells, in the ovarian tissue of women.

Some of these cells are selected before the menstrual period, start to grow and then one of them becomes dominant and ovulation occurs. This process takes approximately 60-70 days.

The low egg reserve hormone AMH starts to decrease as the number of these precursor egg cells decreases. When it falls below a certain level, menopause begins in women.

The low egg reserve hormone AMH remains constant for a month, regardless of the menstrual period. Therefore, the level of this hormone can be measured at any time outside the menstrual period.

When should I start IVF treatment if I have low egg reserve?

If there is low egg reserve (AMH) and pregnancy does not occur despite 6 months of unprotected intercourse over 35 years of age, IVF treatment is the most important alternative.

In younger women, if there is 1 year of unprotected intercourse and the AMH level is below 1.1 ng/ml, it will be useful to recommend IVF treatment.

How does a low egg reserve (AMH) test result increase or decrease?

The low egg reserve hormone AMH decreases with age. In addition, if the blood sample taken while measuring the AMH hormone is stored outside for a long time or depending on the difference in the laboratory kits, it may vary slightly.

When should the egg reserve hormone (AMH) be measured?

The low egg reserve hormone AMH can be measured at any time during menstruation.

What most affects the success of IVF in case of low AMH?

One of the most important issues in the success of IVF in women with low AMH is the number of eggs and the age of the woman.

On the 2nd or 3rd day of the menstrual period, the number of eggs in the ovarian tissue and the low egg reserve (AMH) test are evaluated together by ultrasound. In these patients, the age of the woman affects the result the most. The most important issue in the success of the treatment of these patients is the experience of the physician who will perform the treatment and the type of treatment applied.

Low Egg Reserve (AMH) and Egg Quality

In IVF treatment in women with low egg reserve (AMH),egg quality is lower than in patients with normal egg reserve. Therefore, it is important to apply supportive treatments to improve the egg quality of these patients in terms of IVF success.

These treatments can be in the form of nutritional supplements called antioxidants, growth hormone or male hormone applications.

What should the low egg reserve (AMH) test be?

Low egg reserve means an AMH level below 1.1 ng/ml. However, some women may have a lower number of eggs on ultrasound even if their AMH levels are higher. This is why AMH or egg count alone is not enough to determine low egg reserve. The most accurate way is to evaluate these two parameters together.

How does AMH increase in low egg reserve?

The most popular method applied today to increase AMH in low egg reserve is Prp. Although there are scientific studies showing an increase in egg reserve test AMH with Prp treatment, especially in Greece and Turkey, it has not yet been clearly proven.

What do we not know about low egg reserve amh?

  • Low egg reserve AMH is one of the most important markers of ovarian function. While it is observed at the highest levels until the age of 25, it tends to decrease with age.
  • There are different measurement kits from different companies around the world to measure AMH levels. BECHMAN COULTER, ELISA, picoAMH assay are some of them. Since they measure AMH levels with different antibodies, the results may vary.
  • Low egg reserve AMH may decrease as body mass index increases. There are studies showing a negative association with weight.
  • Low egg reserve AMH level is positively affected by vitamin D level.
Update Date: 27.06.2023
Prof. Dr. Cem Çelik
Prof. Dr. Cem Çelik
Gynecologist and Obstetrician
The content of this page is for informational purposes only.
Please consult your physician for diagnosis and treatment.
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